Lions quarterback Jared Goff matched his career best of five passing touchdowns while hitting 23 of 28 throws for 334 yards. Goff has six touchdown passes and one interception this season.
Detroit wideout Amon-Ra St. Brown has caught 13 passes for 160 yards and is tied for the NFL lead with three touchdown receptions.
"I feel like we were a lot better than we were (in week 1) from everything," St. Brown said. "From the explosive plays, to the communication, to the details, the execution, to taking care of the football. Just the whole top to bottom. ...
"But, anytime you put up 50 in this league is tough against any opponent."
The showing was needed after Detroit struggled in Week 1 while falling 27-13 to the host Green Bay Packers.
Naturally, Goff liked seeing his team quadruple its point total.
"Felt like we were completing a lot of balls and getting down the field with a lot of explosives and the whole thing," Goff said. "It really starts upfront. Those guys pass protect like that, it's going to be tough to stop us. This Monday night, we'd like to throw it like that again."
Baltimore scored 40 points in its season-opening loss to Buffalo, a game in which the Bills scored 16 points in the final four minutes to pull off the 41-40 win. Last week, the Ravens pounded the Cleveland Browns 41-17.
Jackson has six passing touchdowns and one rushing score through two games. He hasn't been intercepted.
Despite the easy victory against the Browns, Baltimore rushed for just 45 yards. Derrick Henry had just 23 yards on 11 carries after rumbling for 169 yards and two scores on 18 carries against the Bills.
"They had a bunch of guys at the line of scrimmage, and they were triggering the run right away," Ravens coach John Harbaugh said. "When you get a run key, you're hitting gaps, running through gaps. I would say they were blitzing the run. It wasn't a blitz call, but it's a blitz reaction to the run."
Baltimore will be without standout defensive tackle Nnamdi Madubuike (neck), who was ruled out Saturday. The two-time Pro Bowler was injured against Cleveland.
Veteran linebacker Kyle Van Noy (hamstring) missed his third straight practice for the Ravens and also was ruled out. Fullback Patrick Ricard (calf) and tight end Isaiah Likely (foot) also will sit out. Likely broke his left foot early in training camp and hasn't played yet this season.
Detroit defensive end Marcus Davenport (chest) will miss the game. Standout left tackle Taylor Decker (shoulder) missed practice Saturday one day after being a full participant. He was listed as questionable.
The Lions also listed linebacker Jack Campbell (ankle), safety Kerby Joseph (knee) and cornerback D.J. Reed (knee) as questionable.
Baltimore has beaten the Lions five straight times and six of seven overall.
--Field Level Media