The backs now face a Miami defense that has held opponents to 87.4 yards a game, the 14th fewest nationally, and 2.8 yards per carry, tied for 12th best.
"We need to find ways to run the ball more effectively and be able to put some pressure on the defense that way, instead of having to throw the ball quite as much," Cardinals coach Jeff Brohm said.
Still, Louisville has been able to put points on the board as Moss, a transfer from Southern California, has thrown for 984 yards on 90-of-131 passing over the past three games.
Injuries in the running game have set up more opportunities for receivers. Senior Chris Bell has set career highs in receptions and yards in back-to-back games, most recently catching 12 passes for 170 yards and two scores against Virginia. Caullin Lacy, who has punt-return touchdowns 75 and 93 yards, ranks second nationally with an average of 151.4 all-purpose yards per game.
If Brown can return to top form from a lower leg injury he has nursed for about a month, he also would provide big-play capabilities. He has scored three touchdowns, with the shortest of those going for 31 yards.
"They've got probably more of an abundance of proven playmakers on their football roster right now, and certainly, they find a way to get them the ball," Miami coach Mario Cristobal said.
Miami, too, has a bevy of playmakers, including quarterback Carson Beck. The Georgia transfer, a leading Heisman Trophy candidate, tops the ACC and ranks fifth nationally with a 73.4% completion rate. He has thrown for 1,213 yards and 11 touchdowns with only three interceptions, but he is set to face the country's eighth-best passing defense that is allowing just 150.4 yards per game.
Freshman receiver Malachi Toney is coming off his best game, a seven-catch, 107-yard, two-touchdown performance the last time the Hurricanes played, a 28-22 win at Florida State two weeks ago.
--Field Level Media