Push those holiday party plans to another time. The NFL Week 15 odds had action on Saturday, Sunday, and Monday.
With the weekend in the books, our attention turns to Monday Night Football as the Philadelphia Eagles look to get back in the win column against the feisty Seattle Seahawks.
We run down the opening NFL Week 15 odds and early adjustments.
NFL Week 15 odds, lines, and spreads
These are the live NFL odds for Week 15, highlighting the best odds available from regulated sportsbooks within your area.
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Chargers vs. Raiders odds
Opening line
- Raiders -3
- Over/Under 34.5
- View full Chargers vs. Raiders line movement
- Read our Chargers vs. Raiders picks and predictions
The look-ahead line had the Chargers as 3.5-point road favorites and the total at 42.5 points, but with Justin Herbert likely out for the season with a broken finger, the Raiders open as 3-point home chalk and the total has trimmed to 34.5 points.
Also see: full Thursday Night Football odds
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Vikings vs. Bengals odds
Opening line
- Bengals -4
- Over/Under 40
- View full Vikings vs. Bengals line movement
- Read our Vikings vs. Bengals picks and predictions
Minnesota walked away with an ugly 3-0 win in Week 14 but didn't feel like a winner. The Vikings benched QB Josh Dobbs for Nick Mullens and star WR Justin Jefferson returned for less than two quarters before leaving the game with a chest injury. He's questionable for this short week on Saturday. Cincinnati opened as a 4-point home favorite with the total at 40 points, which has started to slim.
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Steelers vs. Colts odds
Opening line
- Colts -2.5
- Over/Under 41
- View full Steelers vs. Colts line movement
- Read our Steelers vs. Colts picks and predictions
The Steelers looked bad losing to New England at home on Thursday and opened as a 2.5-point underdog in Indianapolis. Quarterback Kenny Pickett is still out, which means more Mitchell Trubisky. The total opened at 41 points.
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Broncos vs. Lions odds
Opening line
- Lions -4
- Over/Under 46.5
- View full Broncos vs. Lions line movement
- Read our Broncos vs. Lions picks and predictions
After another win by the Broncos and a bad loss from the Lions, Detroit opened as a 4-point home favorite and it didn't take long for that to get knocked down to -3.5 with early action on Denver. This total sits at 46.5 points.
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Texans vs. Titans odds
Opening line
- Titans -3.5
- Over/Under 37.5
- View full Texans vs. Titans line movement
- Read our Texans vs. Titans picks and predictions
The Titans head back home after their thrilling comeback win over the Miami Dolphins on Monday Night Football. The Texans come to town following a tough, 30-6, loss to Zach Wilson and the New York Jets. Oddsmakers opened the Titans as 2.5-point home favorites with a total of 37.5.
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Jets vs. Dolphins odds
Opening line
- Dolphins -10
- Over/Under 40
- View full Jets vs. Dolphins line movement
- Read our Jets vs. Dolphins picks and predictions
The Jets are rolling with Zach Wilson back under center, and they roll into Miami Gardens for a key rivalry battle against the Dolphins. Oddsmakers opened the Fish as 10-point home favorites with a total of 40.
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Bears vs. Browns odds
Opening line
- Browns -3
- Over/Under 38
- View full Bears vs. Browns line movement
- Read our Bears vs. Browns picks and predictions
Cleveland picked up a big win over Jacksonville with veteran Joe Flacco under center. The Browns defense takes aim at Chicago, which has won three of the last four games anchored by a vastly improved defense. This total hit the board at 38 points.
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Chiefs vs. Patriots odds
Opening line
- Patriots +10
- Over/Under 37.5
- View full Chiefs vs. Patriots line movement
- Read our Chiefs vs. Patriots picks and predictions
New England looked solid with QB Bailey Zappe last Thursday and now has a mini bye to prep for Kansas City, which is coming off a home loss to Buffalo on Sunday. The Chiefs have lost three of their last four with a 1-3 ATS mark in that span. This total opened at 37.5 points.
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Falcons vs. Panthers odds
Opening line
- Panthers +3
- Over/Under 35.5
- View full Falcons vs. Panthers line movement
- Read our Falcons vs. Panthers picks and predictions
Atlanta was edged at home by Tampa Bay and now hits the road as field goal favorites in Carolina. The Panthers are coming off a really bad showing in New Orleans and you have to wonder how long the team will keep rookie QB Bryce Young under center. This total opened at 35.5 points and is already down to 34.5.
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Giants vs. Saints odds
Opening line
- Saints -5
- Over/Under 37
- View full Giants vs. Saints line movement
- Read our Giants vs. Saints picks and predictions
The Giants and Tommy Cutlets roll into New Orleans to take on Derek Carr and the Saints on Sunday afternoon. Both side are coming off wins in Week 14, and oddsmakers opened the home team as a 5-point favorite with a total of 37.
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Buccaneers vs. Packers odds
Opening line
- Packers -3.5
- Over/Under 42
- View full Buccaneers vs. Packers line movement
- Read our Buccaneers vs. Packers picks and predictions
The Buccaneers stay on the road for Week 15 after a nice road win over the Falcons in Atlanta last week. The host Packers are coming off a tough loss on Monday Night Football against the New York Giants. Oddsmakers opened the Packers as 3.5-point home favorites with a total of 42.
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Commanders vs. Rams odds
Opening line
- Rams -7
- Over/Under 48.5
- View full Commanders vs. Rams line movement
- Read our Commanders vs. Rams picks and predictions
The Rams almost kept their winning streak alive but fell at Baltimore in overtime. They return home to host the Commanders, who are coming off a bye. Los Angeles opened as a touchdown underdog while the total hit the board at 48.5 and jumped to 49.5 with instant bets on the Over.
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Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
49ers vs. Cardinals odds
Opening line
- Cardinals +13.5
- Over/Under 46.5
- View full 49ers vs. Cardinals line movement
- Read our 49ers vs. Cardinals picks and predictions
San Francisco opened just below a two-touchdown road chalk and some books are already serving 49ers -14. The Niners did have several defensive injuries in their Week 14 win vs. Seattle, watching DL Javon Hargrave, LB Oren Burks, and CB Charvarius Ward leave the game. This total is at 46.5 points.
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Cowboys vs. Bills odds
Opening line
- Bills -2
- Over/Under 49.5
- View full Cowboys vs. Bills line movement
- Read our Cowboys vs. Bills picks and predictions
The Cowboys and Bills both picked up wins last week and are on a collision course for a great matchup in Orchard Park on Sunday afternoon. Oddsmakers opened the Bills as 2-point home favorites with a total of 49.5.
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Ravens vs. Jaguars odds
Opening line
- Jaguars +3
- Over/Under 44
- View full Ravens vs. Jaguars line movement
- Read our Ravens vs. Jaguars picks and predictions
Jacksonville opened between +3 and +3.5 across the industry, suffering their second straight loss in Week 14. The Ravens avoided a big upset with an overtime win against Los Angeles and now bring a three-game winning streak to Jacksonville on Sunday Night Football. The total opened at 44 points.
Also see: full Sunday Night Football odds
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Eagles vs. Seahawks odds
Opening line
- Seahawks +3.5
- Over/Under 47.5
- View full Eagles vs. Seahawks line movement
- Read our Eagles vs. Seahawks picks and predictions
The Eagles come into Monday Night Football off two consecutive losses, and will look to halt their free fall in Seattle against the struggling Seahawks. Oddsmakers opened the Eagles as 3.5-point road favorites with a total of 47.5.
Also see: full Monday Night Football odds
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More weekly NFL odds content
- Week 1 odds
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- Week 18 odds
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