NFL Week 13 Odds and Betting Lines: Browns Favored With Watson Ready to Debut vs Former Team

After missing the first 11 games of the season, Deshaun Watson is finally eligible to debut for the Cleveland Browns — against his former team, the Houston Texans — and the look-ahead Week 13 NFL odds have Cleveland as a road favorite.

Last Updated: Nov 29, 2022 1:40 PM ET Read Time: 8 min
Deshaun Watson Cleveland Browns NFL
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Thanksgiving in is the rearview, which means NFL Week 13 kicks off the home stretch of the season.

Postseason pushes add some spice to the NFL Week 13 odds, with plenty of high-profile pairings. The AFC East headlines Thursday Night Football when the Bills and Patriots add another chapter to their rivalry.

Sunday has some sensational storylines as Tennessee takes on Philadelphia, Miami matches up with San Francisco, and Kansas City is out for revenge in Cincinnati. And of course, we get the debut of Deshaun Watson when Cleveland visits the QB's former team in Houston.

It's lining up to be one of the best slates of the season. Here's a look at the opening NFL Week 13 odds and early action.

These are the live NFL odds for Week 13, highlighting the best odds available from regulated sportsbooks within your area.

Teams on bye: Panthers, Cardinals

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Bills at Patriots odds

Opening line

Patriots +5.5, 45.5 O/U

Why the line moved

1:50 P.M. MONDAY, NOV. 28: After opening the Bills as 5.5-point road favorites Sunday evening, books have taken some Patriots action early on and have slimmed the pointspread to -5 (a few books are offering -4.5). The total is down from an opener of 45.5 to 43.5.

Steelers at Falcons odds

Opening line

Falcons -1.5, 43 O/U

Why the line moved

12:54 P.M. TUESDAY, NOV. 29: The early opener on Sunday evening had the Falcons as 1.5-point home favorites, but a solid win over the Colts on Monday Night Football has moved this pointspread in the direction of the Steelers. If you shop around, this spread can be found anywhere from Falcons -1 to Steelers -1.5. The opening total of 43 is the industry consensus as of Tuesday morning, but there are a few books running with 42.5.

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Broncos at Ravens odds

Opening line

Ravens -7.5, 39.5 O/U

Why the line moved

1:54 P.M. MONDAY, NOV. 28: The betting world is fed up with Russell Wilson and the pathetic Broncos' offense. After opening as 7.5-point road underdogs for Sunday's game, that number is up to +8.5 and +9 depending on your book. After opening at 39.5 and quickly jumping to 40, the total dropped overnight to 38.5.

Packers at Bears odds

Opening line

Bears +3, 43.5 O/U

Why the line moved

12:59 P.M. TUESDAY, NOV. 29: Packers head coach Matt LaFleur said QB Aaron Rodgers is "feeling better" and they will address the situation further over the next couple of days. He said if Rodgers is healthy enough to play, he will play. Books moved the spread from Packers -2/-2.5 to -2.5/-3. The total is still at 42.5.

Jaguars at Lions odds

Opening line

Lions PK, 51.5 O/U

Why the line moved

1:03 P.M. TUESDAY, NOV. 29: After opening at a pick 'em and initially moving in the direction of the Lions, sharp action on the Jaguars has moved this pointspread back over the fence to Jags -1/-1.5. The total is holding steady at 51.5 early in the week.

Browns at Texans odds

Opening line

Texans +6.5, 45 O/U

Why the line moved

1:06 P.M. TUESDAY, NOV. 29: As of Tuesday morning, the pointspread for this Sunday afternoon game is holding at Browns -7. Some juice is starting to pile up on the favorites so this spread could add the hook to -7.5 before too long. The total has seen some upward movement up to 46.5/47 after hitting the board at 45 on Sunday evening.

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Jets at Vikings odds

Opening line

Vikings -3, 42 O/U

Why the line moved

9:00 P.M. SUNDAY, NOV. 27: The Vikings opened as 3-point home chalk taking on their second straight AFC East opponent after knocking off New England on Thanksgiving. The Jets offense was sparked by the QB switch to Mike White, who helped put 31 points on the board in a win over Chicago on Sunday. We are seeing the juice trend toward Minnesota, so a move to -3.5 is not far off. This total opened at 42 points.

Commanders at Giants odds

Opening line

Giants +1, 41 O/U

Why the line moved

1:12 P.M. TUESDAY, NOV. 29: After opening at Commanders -1 and quickly moving to -2, the pointspread for this NFC East rivalry game is up to -2.5 as of Tuesday afternoon. The total is down slightly from the opener, from 41 to 40.5.

Titans at Eagles odds

Opening line

Eagles -6.5, 44.5 O/U

Why the line moved

2:16 P.M. MONDAY, NOV. 28: One of the highlights of the Week 13 schedule goes down in Philadelphia when the Titans come to town to take on the Eagles. Philly is coming off a big 40-33 win over the Packers on Sunday Night Football while the Titans lost at home to the Bengals on Sunday afternoon. Sportsbooks opened the Eagles as 6.5-point favorites and set the opening total at 44.5. As of Monday afternoon the total is steady but the spread is down to Eagles -5.5.

Seahawks at Rams odds

Opening line

Rams +4.5, 42 O/U

Why the line moved

1:18 P.M. TUESDAY, NOV. 29: After already dealing with injuries to star players on offense (Matthew Stafford, Cooper Kupp, Allen Robinson, Tyler Higbee, etc.), the Rams are now faced with a potential high ankle sprain to Aaron Donald. Sportsbooks have adjusted the pointspread for Sunday's game from Seahawks -5 to -7.5 on Monday evening. The total is down slightly from 42/42.5 to 41/41.5.

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Dolphins at 49ers odds

Opening line

49ers -4, 48 O/U

Why the line moved

9:00 P.M. SUNDAY, NOV. 27: This non-conference clash is one of the biggest games of the season, with the red-hot Dolphins and head coach Mike McDaniel taking on his former team, the 49ers, in San Francisco. The Niners opened as big as 4-point home faves but that has shrunk to -3.5 with play on Miami. The total opened at 48 points and is now down to 46.5. San Francisco did lose RB Elijah Mitchell to a knee injury in Week 12.

Chiefs at Bengals odds

Opening line

Bengals +3, 51.5 O/U

Why the line moved

9:00 P.M. SUNDAY, NOV. 27: A rematch of last year’s AFC Championship Game has the Chiefs in Cincinnati, giving a field goal to the Bengals. Early play has been on the home dog, bringing the spread down to Chiefs -2.5. Cincinnati could have WR Ja’Marr Chase and RB Joe Mixon back from injury for this game. The total opened at 51.5 points.

Chargers at Raiders odds

Opening line

Raiders +2.5, 50 O/U

Why the line moved

1:26 P.M. TUESDAY, NOV. 29: After opening at Chargers -2.5 on Sunday evening, the pointspread for this Sunday afternoon game has slimmed to -1.5 at most books. There are still a few trusted shops dealing Chargers -2, so we'll see where the action takes this number over the next few days. The total is holding steady at 50.5.

Colts at Cowboys odds

Opening line

Cowboys -10, 42.5 O/U

Why the line moved

1:32 P.M. TUESDAY, NOV. 29: Coming on the heels of their boring 24-17 loss to the Steelers on Monday Night Football, the world gets treated to another primetime Colts game in Week 13 on Sunday Night Football. Sportsbooks opened the Cowboys as big 10-point home favorites and that number was quickly bet up to -10.5/-11. The total hit betting boards at 42.5 and is up a full point to 43.5 as of Tuesday afternoon.

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Saints at Buccaneers odds

Opening line

Buccaneers -6, 40 O/U

Why the line moved

2:27 P.M. MONDAY, NOV. 28: Early money is all over the visiting Saints and the pointspread has been steadily shortening. The spread opened at Buccaneers -6 and is down to -3.5 as of Monday afternoon. The total is holding at 40.

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