Four short months stand between now and the start of the 2022 NFL season, and we now have a full slate of games to look forward to.
The Week 1 schedule has been released and in typical NFL fashion, there's no shortage of drama. The new season will kickoff with Josh Allen and the Bills visiting the Super Bowl champion Rams, feature America's Team and Tom Brady on Sunday Night Football, then Week 1 closes out with Russell Wilson and the Broncos visiting the Seattle Seahawks.
Here is the full slate of games for opening weekend and the NFL Week 1 odds.
NFL Week 1 Odds
These are the NFL odds for Week 1, headlined by Wilson's return to Seattle with his Broncos.
| Matchup | Time | Spread | Over/Under |
|---|---|---|---|
| Bills at Rams | Thurs, 8:20 p.m. ET | Rams -1 | 52 |
| Saints at Falcons | Sun, 1 p.m. ET | Falcons +3.5 | 42 |
| Browns at Panthers | Sun, 1 p.m. ET | Panthers +3.5 | 42.5 |
| 49ers at Bears | Sun, 1 p.m. ET | Bears +6.5 | 42.5 |
| Steelers at Bengals | Sun, 1 p.m. ET | Bengals -6 | 45 |
| Eagles at Lions | Sun, 1 p.m. ET | Lions +4 | 46.5 |
| Colts at Texans | Sun, 1 p.m. ET | Texans +7.5 | 44.5 |
| Patriots at Dolphins | Sun, 1 p.m. ET | Dolphins -2.5 | 45 |
| Ravens at Jets | Sun, 1 p.m. ET | Jets +4 | 45.5 |
| Jaguars at Commanders | Sun, 1 p.m. ET | Commanders -4 | 44.5 |
| Chiefs at Cardinals | Sun, 4:25 p.m. ET | Cardinals +3 | 53 |
| Raiders at Chargers | Sun, 4:25 p.m. ET | Chargers -4 | 52 |
| Packers at Vikings | Sun, 4:25 p.m. ET | Vikings +1 | 49 |
| Giants at Titans | Sun, 4:25 p.m. ET | Titans -7 | 44 |
| Buccaneers at Cowboys | Sun, 8:20 p.m. ET | Cowboys +3 | 51 |
| Broncos at Seahawks | Mon, 8:15 p.m. ET | Seahawks +4 | 41 |
Odds courtesy of DraftKings Sportsbook as of May 12, 2022.
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