NFL Week 1 Odds: Rams Slight Favorites Hosting Bills on TNF

We're inching closer to the 2022 NFL season, with the full season's schedule released on Thursday night. The league kicked things off with the opening week slate and we'll bring you the full NFL Week 1 odds here.

Last Updated: May 12, 2022 7:14 PM ET Read Time: 4 min
Josh Allen Buffalo Bills NFL
Photo By - USA TODAY Sports

Four short months stand between now and the start of the 2022 NFL season, and we now have a full slate of games to look forward to. 

The Week 1 schedule has been released and in typical NFL fashion, there's no shortage of drama. The new season will kickoff with Josh Allen and the Bills visiting the Super Bowl champion Rams, feature America's Team and Tom Brady on Sunday Night Football, then Week 1 closes out with Russell Wilson and the Broncos visiting the Seattle Seahawks. 

Here is the full slate of games for opening weekend and the NFL Week 1 odds. 

These are the NFL odds for Week 1, headlined by Wilson's return to Seattle with his Broncos.

Matchup Time Spread Over/Under
Bills at Rams Thurs, 8:20 p.m. ET Rams -1 52
Saints at Falcons Sun, 1 p.m. ET Falcons +3.5 42
Browns at Panthers Sun, 1 p.m. ET Panthers +3.5 42.5
49ers at Bears Sun, 1 p.m. ET Bears +6.5 42.5
Steelers at Bengals Sun, 1 p.m. ET Bengals -6 45
Eagles at Lions Sun, 1 p.m. ET Lions +4 46.5
Colts at Texans Sun, 1 p.m. ET Texans +7.5 44.5
Patriots at Dolphins Sun, 1 p.m. ET Dolphins -2.5 45
Ravens at Jets Sun, 1 p.m. ET Jets +4 45.5
Jaguars at Commanders Sun, 1 p.m. ET Commanders -4 44.5
Chiefs at Cardinals Sun, 4:25 p.m. ET Cardinals +3 53
Raiders at Chargers Sun, 4:25 p.m. ET Chargers -4 52
Packers at Vikings Sun, 4:25 p.m. ET Vikings +1 49
Giants at Titans Sun, 4:25 p.m. ET Titans -7 44
Buccaneers at Cowboys Sun, 8:20 p.m. ET Cowboys +3 51
Broncos at Seahawks Mon, 8:15 p.m. ET Seahawks +4 41

Odds courtesy of DraftKings Sportsbook as of May 12, 2022.

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